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    Nutrient supplements can give antidepressants a boost

    An international evidence review has found that certain nutritional supplements can increase the effectiveness of antidepressants for people with clinical depression.

    Omega 3 fish oils, S-adenosylmethionine (SAMe), methylfolate (bioactive form of folate) and Vitamin D, were all found to boost the effects of medication.

    University of Melbourne and Harvard researchers examined 40 clinical trials worldwide, alongside a systematic review of the evidence for using nutrient supplements (known as nutraceuticals) to treat clinical depression in tandem with antidepressants such as SSRIs, SNRIs^ and tricyclics^^.

    Head of the ARCADIA Mental Health Research Group at the University of Melbourne, Dr Jerome Sarris, led the meta-analysis, published in theAmerican Journal of Psychiatry.

    "The strongest finding from our review was that Omega 3 fish oil -- in combination with antidepressants -- had a statistically significant effect over a placebo," Dr Sarris said.

    "Many studies have shown Omega 3s are very good for general brain health and improving mood, but this is the first analysis of studies that looks at using them in combination with antidepressant medication.

    "The difference for patients taking both antidepressants and Omega 3, compared to a placebo, was highly significant. This is an exciting finding because here we have a safe, evidence-based approach that could be considered a mainstream treatment."

    The University of Melbourne research team also found good evidence for methylfolate, Vitamin D, and SAMe as a mood enhancing therapy when taken with antidepressants. They reported mixed results for zinc, vitamin C and tryptophan (an amino acid). Folic acid didn't work particularly well, nor did inositol.

    "A large proportion of people who have depression do not reach remission after one or two courses of antidepressant medication," Dr Sarris said.

    "Millions of people in Australia and hundreds of millions worldwide currently take antidepressants. There's real potential here to improve the mental health of people who have an inadequate response to them."

    Dr Sarris said medical professionals may be hesitant to prescribe nutraceuticals alongside pharmaceuticals, simply because there has been a lack of scientific evidence around their efficacy.

    "Medical practitioners are aware of the benefits of omega 3 fatty acids, but are probably unaware that one can combine them with antidepressant medication for a potentially better outcome," he said.

    The researchers found no major safety concerns in combining the two therapies, but stressed that people on antidepressants should always consult with their health professional before taking nutraceuticals and should be aware these supplements can differ in quality.

    "We're not telling people to rush out and buy buckets of supplements. Always speak to your medical professional before changing or initiating a treatment," Dr Sarris said.

    The researchers are currently conducting a National Health and Medical Research Council study using a combination of these nutraceuticals for depression.

    Source:University of Melbourne

    What do my cravings say about my health?

    After a stressful day, it's almost second nature to laze on the couch and drown our sorrows in a bowl of ice-cream or potato chips. Soon, we glance down and realize we've managed to consume the entire pint or bag. So, what makes these foods so irresistible -- causing us to mindlessly indulge? According to a Texas A&M Health Science Center registered dietitian, there's a difference in what you think your body craves and what it actually needs.

    "Eating a recommended, balanced diet will cover most of your cravings," said Taylor Newhouse, registered dietitian, with the Texas A&M School of Public Health. However, as a society, we tend to avoid the green things on our plate and we miss out on key nutrients our body needs."

    The insatiable sweet tooth

    Fluctuating blood sugar levels may be to blame if you immediately reach for sweet snacks. "As blood glucose (blood sugar) levels change throughout the day, the body tries to keep these levels stable," Newhouse said. "Still, this is counterproductive; consuming sugary foods will only feed this addiction and result in more cravings."

    In fact, sugar releases endorphins within the body that make you feel happy or comfortable. Newhouse said this 'sugar high' can also lead to the overconsumption of simple carbohydrates and result in binging -- now considered an official eating disorder. "We tend to overconsume carbohydrates because they're easily digestible and give us the same boost as sugar," she said. "It's imperative we learn to replace that 'high' with a healthy activity we enjoy, like exercising."

    However, it might not be smart to exercise too hard if you're trying to kick a craving. Intense exercise can also tell the body when carbohydrate stores have been depleted. If you're working out, and suddenly decide you need a burger on the way home, this is your body's way of saying it needs nutrients to recover.

    "Incorporating more sweet fruits like berries or apples into your diet, along with dark leafy greens like broccoli or kale -- which are high in calcium -- will help to reduce the need to hit the company vending machine during the day," Newhouse said.

    Hungry? Don't eat a chocolate bar…

    Chocolate, like coffee, is almost an addiction. Scarfing down a chocolatey confection when we're stressed is almost an involuntary act, since stress can produce chocolate cravings. Unsurprisingly, chocolate is also known to raise brain serotonin levels which generate feelings of happiness or pleasure. This may be why we can feel 'addicted' to chocolate or sugar.

    Another reason we may crave chocolate is due to a magnesium deficiency (chocolate contains high levels of magnesium). Women may also pine for chocolate due to hormonal changes, or, snacking frequently on chocolate could mean the body has a vitamin B shortage.

    "It's okay to have a little chocolate to subdue cravings," Newhouse said. "But, you should also supplement with healthier options like mixed nuts, a banana, or, sauté greens like spinach with lemon, olive oil, garlic and rosemary for a sweeter flavor."

    I'll have fries with that

    We're all guilty of stress-eating and binging on certain foods when we're bored or overwhelmed. Newhouse noted during periods of stress our body will naturally crave fast food or fattier foods.

    "This could mean you're deficient in essential fatty acids like omega-3s," she said. "Our bodies do not naturally make omega-3s, but you can supplement them or cook with oils like canola oil, extra virgin olive oil or hemp oil to up your intake."

    Indulging shamelessly in a large order of fries could also mean our body is actually craving fat, however, not all fats are created equal. The next time you feel the need to order anything fried try supplementing with healthier options like avocados and raw nuts -- which are high in 'good' fats.

    How to pass on the salt

    If you suddenly develop an intense desire for chips or pretzels, your may be iron-deficient. "When we crave salty things, it's a signal to consume foods with more iron," Newhouse said. "Eating foods high in calcium, potassium and iron can combat these cravings."

    Drinking a glass of milk, eating yogurt or making a salad with dark, leafy greens will all aid in keeping our sodium habit at bay while increasing calcium and iron levels. To up potassium intake, Newhouse recommends snacking on a banana, sweet potatoes, avocados or citrus fruits.

    Important to know: During intense exercise or a difficult workout, your body will actually lose sodium and seek to replace it. "If you're outside working or working out, your body will lose salt through the process of sweating," Newhouse said. "This can increase your cravings for salty foods."

    Are you just dehydrated?

    Most hunger pangs and cravings usually have a simple solution: Drink more water. "We often misinterpret the signals our body is giving us," Newhouse said. "As a society, we are chronically dehydrated (Just so you know: thirst is actually the last resort signal for dehydration). The next time you reach for something sweet or salty try quelling the craving with a tall glass of water. You may be surprised at the result."

    A hankering for kale? It's a thing

    Yes, sometimes we do crave fresh food and vegetables like kale or broccoli. Many times this desire for fresh ingredients appears when your body needs more Vitamin C, calcium, iron or magnesium. "If you begin to crave fruits and vegetables, then indulge away!" Newhouse said. "However, if you're trying to limit your carbohydrate intake, you should still pay attention to the amount you eat."

    It's all about balance

    A healthy diet and lifestyle hinge on one thing: Balance. Newhouse said it's perfectly normal to satisfy cravings in moderation, but, you should also assess your diet during these instances. "Think about the last time you consumed foods in every single color. If you can't remember the last time you ate a tomato or berries, try snacking on those," she advised.

    The above post is reprinted from materials provided by Texas A&M University. Note: Materials may be edited for content and length.

    Omega-3 lowers childhood aggression in short term

    Incorporating omega-3, vitamins and mineral supplements into the diets of children with extreme aggression can reduce this problem behavior in the short term, especially its more impulsive, emotional form, according to University of Pennsylvania researchers who published their findings in theJournal of Child Psychology and Psychiatry.

    Adrian Raine, the Richard Perry University Professor of Criminology, Psychology and Psychiatry, has spent his career looking at how the brain's biological functioning affects antisocial behavior. He focuses specifically on understanding these actions and learning how to modify them, whether with something benign like a child acting out or with something extreme, in the case of a homicidal killer.

    "How do you change the brain to make people better?" he asked. "How can we improve brain functioning to improve behavior?"

    These questions formed the foundation for work Raine had previously done with adolescents on the African island of Mauritius. In a randomized control trial, one group received omega-3 supplements for six months, the other didn't. Those taking the fish oil saw a reduction in aggressive and antisocial behavior.

    "That was my starting point," he said. "I was really excited about the results we published there."

    Mauritius, however, is a tropical climate and a different culture from the United States, so Raine, a Penn Integrates Knowledge Professor, decided to test a new version of the study in Philadelphia, to aim for more broadly applicable outcomes. He partnered with Therese Richmond, the Andrea B. Laporte Professor of Nursing and associate dean for research and innovation, and several other Penn faculty, including Rose Cheney of the Perelman School of Medicine and Jill Portnoy of the Criminology Department in the School of Arts & Sciences.

    The Philadelphia randomized control study placed 290 11- and 12-year-olds with a history of violence into four groups: The first received omega-3 in the form of juice, as well as multivitamins and calcium for three months. For that same duration, a second group participated in cognitive behavioral therapy, or CBT, which included meeting weekly for an hour, with time split between the child, the parent and with both together.

    "Sessions focused on the links between thoughts, feelings and behaviors and also practicing alternative actions the children could take to deal with difficult situations rather than to emotionally react to something," said Richmond, who supervised the clinical trial. "It's helping the child build a toolbox of ways to interact with others. For example, if I'm angry, how might I cope with anger other than physically striking out?"All participants got homework, too.

    A third group in the study took the supplements and participated in CBT, and a fourth received resources and information targeted at reducing aggressive behavior. Blood samples at the experiment's start and conclusion measured omega-3 levels in each child.

    "Immediately after three months of the nutritional intervention rich in omega-3s, we found a decrease in the children's reporting of their aggressive behavior," Richmond said. The team also followed up three and six months later.

    At the first check-in, participants getting the combination of CBT and omega-3s reported less aggression than the control group and the therapy-only group. By the final check-in, however, any positive effects had dissipated. What remains unknown is whether continued use of omega-3s would lead to a long-term reduction in antisocial behavior.

    There were other minor limitations to the research. For one, self-reporting completed by parents and children didn't line up. The 11- and 12-year-olds in the omega-3 and CBT-supplement groups noted fewer aggressive behaviors; their parents said such tendencies hadn't changed. Also, some participants dropped out before the study had finished.

    Despite these challenges, Raine, Richmond and their colleagues said the findings provide some important insight.

    "No matter what program you use, could adding omega-3s to your treatment help?" Raine asked. "This suggests it could."

    And though the work answers some questions, it also creates new ones, which returns to a larger point regarding the mind-action connection: It's complicated.

    "We can't oversimplify the complexity of antisocial behavior. There are many causes," Raine said. "It's not just the brain. Is it a piece of the jigsaw puzzle? I think it is." 

    Funding for the research came from the Pennsylvania Department of Health, the Clinical & Translational Research Center at the Perelman School of Medicine and the National Institute on Alcohol Abuse and Alcoholism.

    Story Source:

    The above post is reprinted from materials provided by University of Pennsylvania. Note: Materials may be edited for content and length.

    Many with migraines may have vitamin deficiencies, says study


    A high percentage of children, teens and young adults with migraines appear to have mild deficiencies in vitamin D riboflavin and coenzyme Q10 - a vitamin-like substance found in every cell of the body that is used to produce energy for cell growth and maintenance.

    These deficiencies may be involved in patients who experience migraines, but that is unclear based on existing studies.

    "Further studies are needed to elucidate whether vitamin supplementation is effective in migraine patients in general, and whether patients with mild deficiency are more likely to benefit from supplementation," says Suzanne Hagler, MD, a Headache Medicine fellow in the division of Neurology at Cincinnati Children's Hospital Medical Center and lead author of the study.

    Dr. Hagler and colleagues at Cincinnati Children's conducted the study among patients at the Cincinnati Children's Headache Center. She presented her findings at the 58th Annual Scientific Meeting of the American Headache Society in San Diego.

    Dr. Hagler's study drew from a database that included patients with migraines who, according to Headache Center practice, had baseline blood levels checked for vitamin D, riboflavin, coenzyme Q10 and folate, all of which were implicated in migraines, to some degree, by previous and sometimes conflicting studies. Many were put on preventive migraine medications and received vitamin supplementation, if levels were low. Because few received vitamins alone, the researchers were unable to determine vitamin effectiveness in preventing migraines.

    She found that girls and young woman were more likely than boys and young men to have coenzyme Q10 deficiencies at baseline. Boys and young men were more likely to have vitamin D deficiency. It was unclear whether there were folate deficiencies. Patients with chronic migraines were more likely to have coenzyme Q10 and riboflavin deficiencies than those with episodic migraines.

    Previous studies have indicated that certain vitamins and vitamin deficiencies may be important in the migraine process. Studies using vitamins to prevent migraines, however, have had conflicting success.

    Source: Cincinnati Children's Hospital Medical Center

     

     

     

    What to look for in a Probiotic

    Having a healthy balance of good intestinal flora is one of the most important aspects of health. If the ratio of bad bacteria in the gut begins to outnumber the good bacteria it can lead to a host of health problems.

    Many take probiotics on a daily basis for general health. If you have been on antibiotics to knock out a bug it is important to remember antibiotics also wipe out much of the good bacteria. After antibiotics is a time probiotics are often used to replenish the good bacteria.

    When shopping for Acidophilus / Probiotics it is important to make sure they are stored in the refrigerator at the store where they are bought to ensure potency. A good dose of probiotics would be 8 billion to 50 billion.

    It is also important to look at the amount of probiotic strains in the product. One rule of thumb is to look for a broad variety of strains. 4 different strains would be on the low side while 10 different strains would be optimal.

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